HIV Patient Becomes World’s Second AIDS Cure Hope
By Kate Kelland (Health and Science Correspondent)
LONDON, March 4 (Reuters) – An HIV-positive man in Britain has become the second known adult worldwide to be cleared of the AIDS virus after he received a bone marrow transplant from an HIV-resistant donor, his doctors said.
Almost three years after he received bone marrow stem cells from a donor with a rare genetic mutation that resists HIV infection – and more than 18 months after he came off antiretroviral drugs – highly sensitive tests still show no trace of the man’s previous HIV infection.
“There is no virus there that we can measure. We can’t detect anything,” said Ravindra Gupta, a professor and HIV biologist who co-led a team of doctors treating the man.
AIDS experts said the case is a proof of the concept that scientists will one day be able to end AIDS, and marks a “critical moment” in the search for an HIV cure, but does not mean that cure has already been found.
Gupta described his patient as “functionally cured” and “in remission”, but cautioned: “It’s too early to say he’s cured.”
The man is being called “the London patient”, in part because his case is similar to the first known case of a functional cure of HIV – in an American man, Timothy Brown, who became known as the Berlin patient when he underwent similar treatment in Germany in 2007 which also cleared his HIV.
Brown, who had been living in Berlin, has since moved to the United States and, according to HIV experts, is still HIV-free.
Some 37 million people worldwide are currently infected with HIV and the AIDS pandemic has killed about 35 million people worldwide since it began in the 1980s. Scientific research into the complex virus has in recent years led to the development of drug combinations that can keep it at bay in most patients.
Gupta, now at Cambridge University, treated the London patient when he was working at University College London. The man had contracted HIV in 2003, Gupta said, and in 2012 was also diagnosed with a type of blood cancer called Hodgkin’s Lymphoma